Abstract: The research on the relationship between ecological environment and economic development has important theoretical and practical significance for promoting the construction of ecological civilization in the new era and realizing high-quality economic development. Based on domestic literature on the relationship between ecological environment and economic development during 2011-2021, the mapping knowledge domain is used to analyze the hot topics and development trends in this field. The results show that increasing attention has been paid to this field, and the related research involves more and more interdisciplinary intersections and integration. The coupling coordination between regional ecological environment and economic development, the idea of ecological civilization construction and sustainable development, the connotation, evaluation and realization path of regional high-quality development, and new urbanization are the hot topics in this field. The coordination and symbiosis between economic development and ecological environment in typical regions and how to realize the high-quality development are the future trends.